In the Christmas Eve in New York, the lonely divorced publisher Rose Harrison (Susan Sarandon) expects for a miracle to improve the health of her mother, interned in a hospital with Alzheimer. She feels sorry for the patient of the room in front of her mother's and meets his visitor (Robin Williams). Meanwhile, the Latin Nina Vasquez (Pen?lope Cruz) breaks her engagement with her beloved fianc? Mike (Paul Walker) due to his suffocating jealousy, but misses him. Mike is stalked by the stranger bartender Artie Venzuela (Alan Arkin). The poor Jules (Marcus Thomas) expects to spend the Christmas night in the hospital, where he spent the best Christmas of his life when he was a teenager. The lives of some of these characters cross with others along the night.
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